Symbol
Name
ID

Ntrk2
neurotrophic tyrosine kinase, receptor, type 2
MGI:97384

Phenotype annotations related to nervous system

*	Aspects of the system are reported to show a normal phenotype.
	Darker colors indicate more annotations

Human Phenotypes

Secondary microcephaly

Spastic diplegia

Delayed myelination

EEG abnormality

Hypsarrhythmia

Abnormal nonverbal communicative behavior

Absent speech

Delayed speech and language development

Lack of spontaneous play

Impaired ability to form peer relationships

Autism

Inflexible adherence to routines

Motor stereotypy

Restrictive behavior

Intellectual disability

Intellectual disability, severe

Hyperreflexia

Inability to walk

Epileptic encephalopathy

Global developmental delay

Seizure

Status epilepticus

Disease(s) Associated with NTRK2

autistic disorder

developmental and epileptic encephalopathy 58

Mouse Phenotypes

nervous system phenotype

decreased kindling response

increased susceptibility to dopaminergic neuron neurotoxicity

abnormal neuron differentiation

abnormal axon extension

abnormal axon fasciculation

abnormal neuronal migration

abnormal cochlear OHC afferent innervation pattern

abnormal type I vestibular cell

abnormal brain morphology

abnormal cortical plate morphology

abnormal cerebellum development

small facial motor nucleus

abnormal amygdala morphology

abnormal cerebral cortex morphology

abnormal somatosensory cortex morphology

abnormal barrel cortex morphology

abnormal visual cortex morphology

abnormal Purkinje cell dendrite morphology

astrocytosis

gliosis

abnormal innervation

abnormal sensory neuron innervation pattern

abnormal neuron morphology

abnormal dopaminergic neuron morphology

decreased dopaminergic neuron number

decreased motor neuron number

abnormal myelin sheath morphology

abnormal dendrite morphology

decreased neuron number

decreased sensory neuron number

decreased amacrine cell number

decreased retina ganglion cell number

abnormal retina ganglion cell morphology

abnormal retina rod cell outer segment morphology

abnormal synapse morphology

abnormal somatic nervous system morphology

abnormal cochlear ganglion morphology

small cochlear ganglion

small geniculate ganglion

small petrosal ganglion

small trigeminal ganglion

small nodose ganglion

abnormal vestibular ganglion morphology

small vestibular ganglion

abnormal optic nerve morphology

abnormal vestibulocochlear nerve morphology

abnormal vestibular nerve morphology

abnormal somatic sensory system morphology

absent hair-down neurons

small L4 dorsal root ganglion

small dorsal root ganglion

neurodegeneration

abnormal myelination

demyelination

abnormal peripheral nervous system regeneration

abnormal GABAergic neuron physiology

impaired synaptic plasticity

abnormal excitatory postsynaptic potential

abnormal long-term potentiation

reduced long-term potentiation

decreased prepulse inhibition

Availability

Mouse Genotype

Ntrk2^tm1.1Tes/Ntrk2^tm1.1Tes

Ntrk2^tm1Bbd/Ntrk2^tm1Bbd

Ntrk2^tm1Bxu/Ntrk2^tm1Bxu

Ntrk2^tm1Ddg/Ntrk2^tm1Ddg

Ntrk2^tm1Kln/Ntrk2^tm1Kln

Ntrk2^tm1Lfp/Ntrk2^tm1Lfp

Ntrk2^tm1Lfr/Ntrk2^tm1Lfr

Ntrk2^tm1Mini/Ntrk2^tm1Mini

Ntrk2^tm1Rohr/Ntrk2^tm1Rohr

Ntrk2^tm2.1Ddg/Ntrk2^tm2.1Ddg

Ntrk2^tm2.1Mini/Ntrk2^tm2.1Mini

Ntrk2^tm2.1Tes/Ntrk2^tm2.1Tes

Ntrk2^tm1.1Lfr/Ntrk2⁺

Ntrk2^{tm1b(EUCOMM)Wtsi}/Ntrk2⁺

Ntrk2^tm1Bbd/Ntrk2^tm1Kln

Ntrk2^tm1Lfr/Ntrk2⁺

Ntrk2^tm1Jom/Ntrk2^tm1Jom
Tg(Syn1-cre)671Jxm/0 (conditional)

Ntrk2^tm1Jom/Ntrk2^tm1Jom
Tg(GFAP-cre)25Mes/0 (conditional)

Ntrk2^tm1Lfr/Ntrk2^tm1Lfr
Tg(Camk2a-cre)1Lfr/0 (conditional)

Ntrk2^tm2Kln/Ntrk2^tm2Kln
Tg(Camk2a-cre)159Kln/? (conditional)

Ntrk2^tm2Kln/Ntrk2^tm2Kln
Tg(Nes-cre)1Kln/0 (conditional)

Ntrk2^tm2Kln/Ntrk2^tm2Kln
Tg(Penk-cre,-lacZ)1Mini/0 (conditional)

Ntrk2^tm2Kln/Ntrk2^tm2Kln
Tg(Cck-cre,-lacZ)1Mini/0 (conditional)

Ntrk2^tm2Lfr/Ntrk2^tm2Lfr
Tg(Six3-cre)69Frty/?
Tg(Thy1-YFP)HJrs/? (conditional)

Ntrk2^tm4.1Ddg/Ntrk2^tm4.1Ddg
Avil^tm2(cre)Fawa/Avil⁺ (conditional)

Ntrk2^tm1Bbd/Ntrk2^tm2Kln
Tg(Camk2a-cre)159Kln/0 (conditional)

Ntrk2^tm1Jom/Ntrk2⁺
Tg(Syn1-cre)671Jxm/0 (conditional)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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